Dab Phim Nyuj Vais Tshuaj Khwv Ntau Yam Kom Zam Txau

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Los ntawm Jennifer Coates, DVM

Cov tsiaj uas muaj ntau yam thiab / lossis muaj teeb meem kev noj qab haus huv feem ntau tau noj tshuaj ntau, thiab lawv siv sij hawm ntau dua, qhov kev pheej hmoo loj tshwm sim tuaj. Kev sib cuam tshuam txog yeeb tshuaj tau tshwm sim los ntawm kev hloov pauv hauv lub cev kev muaj peev xwm nqus tau, txuas ntxiv, lossis tso tshuaj tawm tsam (nrog rau lwm yam, tsis tshua pom muaj), tab sis cov kev cuam tshuam ua ob pawg:

• Txo hauv cov txiaj ntsig ntawm ib lossis ntau dua ntawm cov tshuaj
• Ib qho kev pheej hmoo ntau uas tsis tshwm sim tuaj

Cia saib qee cov tshuaj uas tuaj yeem cuam tshuam nrog kev cuam tshuam thiab dab tsi tuaj yeem ua los tiv thaiv peb cov tsiaj.

NSAIDs thiab Corticosteroids

Kev siv tshuaj tua kabmob tsis siv tshuaj (Rimadyl, Metacam, Deramaxx, Etogesic), thiab lwm yam) thiab corticosteroids (prednisone, triamcinolone, dexamethasone, thiab lwm yam) yog ob qho ntawm cov tshuaj feem ntau hais tawm ntawm cov tshuaj hauv cov tshuaj veterinary. Hmoov tsis zoo, thaum lawv muab rau tib lub sijhawm, lossis txawm tsis dhau ob peb hnub ntawm ib leeg, kev mob plab hnyuv yuav tshwm sim. Cov tsiaj cuam tshuam yuav muaj qhov tsis qab los noj mov, ntuav, thiab zawv plab, thiab tuaj yeem txhim kho qhov mob uas ua rau los ntshav lossis txawm tsim qhov nyob rau sab hauv GI.

Raws li txoj cai ntawm tus ntiv tes xoo, tus tsiaj yuav tsum tsis txhob noj NSAIDs thiab corticosteroids tib lub sijhawm. Yog tias nws yog qhov tsim nyog rau tus tsiaj uas nyob rau ib qho ntawm cov hom tshuaj no los pib noj lwm, kws kho tsiaj yuav pom zoo kom ntxuav lub sijhawm li ntawm tsib hnub lossis kom tiv thaiv kev cuam tshuam ntawm cov tshuaj hauv tus tsiaj lub cev.

Cimetidine

Cimetidine (Tagamet) yog ib qho antacid uas tuaj yeem siv los kho lossis tiv thaiv qhov mob hauv qhov ncauj ntawm lub plab zom mov. Nws tseem inhibits (qee qhov block) ib hom tshwj xeeb ntawm enzyme hu ua Cytochrome P450 (CYP). Ntau yam tshuaj siv CYP ua ib feem ntawm cov txheej txheem ntawm kev tshem tawm hauv lub cev. Yog li, yog tias koj muab cov tsiaj cimetidine thiab ib qho ntawm lwm cov tshuaj no (theophylline, aminophylline, lidocaine, thiab diazepam, rau npe rau ob peb), nws muaj ntau dua uas tus tsiaj yuav tsim kev phiv zoo ib yam li cov uas pom nrog overdoses ntawm cov tshuaj nyob rau hauv nqe lus nug. Piv txwv li, tus tsiaj uas noj cimetidine thiab theophylline yuav dhau los ua neeg tsis paub qab hau, lub plawv dhia ceev ceev, lossis nws tseem muaj chua leeg.

Cimetidine tsis yog tib lub tshuaj uas tiv thaiv CYP. Lwm qhov kev siv tshuaj uas muaj qhov zoo sib xws xws li tshuaj tua kab mob ketoconazole, tshuaj tiv thaiv kab mob plab acid omeprazole, thiab qee yam tshuaj tua kab mob zoo li erythromycin thiab enrofloxacin. Yog tias muaj kev sib cuam tshuam nrog yeeb tshuaj nrog CYP, yuav tsum siv lwm txoj tshuaj. Piv txwv, cov tshuaj antacids ranitidine (Zantac) thiab famotidine (Pepcid) feem ntau tuaj yeem hloov chaw rau cimetidine.

Phenobarbital

Hauv kev sib piv rau cimetidine, phenobarbital nthuav tawm qhov teeb meem rov qab thaum nws los txog rau kev sib cuam tshuam yeeb tshuaj. Ib qho tshuaj noj tiv thaiv kom qaug dab peg, phenobarbital ua rau lub cev tsim ntau CYP cov enzymes, uas ua kom pom kev tshem tawm thiab txo qis ntawm ntau yam tshuaj, suav nrog digoxin, glucocorticoids, amitriptyline, clomipramine, theophylline, thiab lidocaine. Qhov nyhuv no tau pom hauv cov dev tab sis tsis yog miv.

Qhov kev xav tau, phenobarbital's cuam tshuam rau CYP cov enzymes kuj tseem ua rau kom qhov kev tshem ntawm phenobarbital tawm ntawm lub cev. Yog li no, ntau tus dev yuav tsum nce rau hauv lawv cov phenobarbital koob nyob rau lub sijhawm kom tswj hwm tib theem ntawm kev chua leeg. Txhawm rau pab txiav txim siab yog tias tus tsiaj tau txais qhov tshuaj uas tsim nyog ntawm cov tshuaj, kws kho tsiaj yuav soj ntsuam cov tshuaj hauv cov ntshav, tus txheej txheem uas hu ua kev saib xyuas tshuaj.

Serotonin Mob

Serotonin yog neurotransmitter, ib yam tshuaj uas ib txwm muaj nyob hauv lub hlwb (thiab lwm qhov ntawm lub cev) uas cuam tshuam rau txoj kev hauv lub leeg "sib tham" sib. Ntau hom tshuaj feem ntau tau muab rau cov tsiaj nce serotonin ntau ntau hauv lub hlwb, thiab thaum lawv siv ua ke, lawv cov txiaj ntsig ua ke yuav ua rau muaj kev phom sij thiab tuaj yeem ua kom tuag taus hu ua serotonin syndrome.

Cov tshuaj uas tuaj yeem ua lub luag haujlwm hauv serotonin syndrome hauv cov tsiaj muaj xws li Anipryl (selegiline lossis L-deprenyl), Mitaban thiab Preventic (amitraz), Clomicalm (clomipramine), Reconcile thiab Prozac (fluoxetine), thiab amitriptyline. Cov tshuaj no yuav tsum tsis txhob muab rau tib lub sijhawm thiab ntxuav lub sijhawm uas ntau ntau lub asthiv tuaj yeem tsim nyog thaum hloov mus rau lwm tus. Cov tsos mob ntawm serotonin syndrome muaj xws li tsis qab los noj mov, ntuav, raws plab, mob plab, ua kom lub plawv dhia thiab lub cev kub, tshee tshee, tawv ntswg, tsis hnov qab, tsis pom kev, ntshav siab, thiab tuag.

Tiv Thaiv Txheeb Yeeb Hauv Tsiaj Hauv Tsiaj

Yog lawm, muaj ntau yam kev sib txuam tshuaj ntau dua li cov tau hais ntawm no. Txhawm rau tiv thaiv koj cov tsiaj, nco ntsoov khaws koj tus kws kho tsiaj kom zoo rau tag nrho cov tsiaj cov tshuaj (nrog rau cov tshuaj ntxiv, cov khoom muag tom khw, cov khoom sib txawv hauv cov khoom noj, thiab lwm yam) uas koj tab tom muab rau. Yog tias koj tus tsiaj noj qab haus huv yuav ua rau nws rov qab zuj zus thiab qhov ua rau nws tsis tuaj yeem pom sai sai, nws tsis mob siab yog tias qhov tshuaj yeeb tshuaj puas tuaj yeem ua txhaum. Hmoov tsis zoo, kev tshawb fawb tsiaj veterinary yog ib qho tsis sib xws nyob hauv thaj chaw no, yog li kev sib txuam tshuaj tsawg dua qee zaum kev kuaj mob uas siv cov ntaub ntawv los ntawm kev ua haujlwm ntawm tib neeg cov tshuaj lossis tsuas yog hloov kho cov tsiaj cov tshuaj los saib seb qhov teeb meem ntawd daws tau.