Siv Monoclonal Antibody Los Kho Lymphoma Hauv Dev

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Cardiff qhov hloov tshiab kawg tau hais txog nws pib kev kho mob tshuaj (saib tom qab Tshem Tawm Cancer, Siv Tshuaj Kho Mob los Tiv Thaiv Kev Kub Ntxhov), yog li hauv ntu no kuv yuav nkag mus rau ib qho tshiab ntawm kev kho mob cancer.

Thaum Cardiff ua ntej dhau los ntawm kev siv tshuaj kho mob, txij thaum Lub Ib Hlis mus txog Lub Xya Hli 2014, nws tau txais cov txheej txheem zoo thiab muaj pov thawj hu ua University of Wattleon-Madison Canine Lymphoma raws cai (aka CHOP). Ntawm chav kawm, Kuv tseem tau muab nws nutraceuticals ( tshuaj ntsuab), tshuaj ntsuab, tag nrho cov zaub mov noj zaub mov noj, acupuncture, thiab lwm yam kev kho mob kom txaus nws cov tshuaj kho mob thiab pab tswj kev phiv.

Lub sijhawm no, Cardiff tseem tabtom tau txais CHOP, tab sis nws tseem yuav tau txais kev kho mob tshiab uas lub hom phiaj qhia nws lub cev tiv thaiv kab mob kom paub txog cov qog nqaij hlav cancer tshiab thiab pab txhawb lawv txoj kev puas tsuaj ua ntej lawv tsim cov qog nqaij hlav tshiab. Nws tau hu ua T-cell monoclonal antibody (MAb).

Tus Antibody yog dab tsi?

Lub cev tiv thaiv kab mob yog tiv thaiv kab mob tiv thaiv kab mob hauv lub cev uas tsim tawm los teb rau ib qho tshuaj uas lub cev tau lossis tsis dhau los tau raug tiv thaiv. Qhov khoom ntawd feem ntau yog kis tau tus kab mob, nrog rau cov kab mob, kab mob, hu ua fungi, thiab lwm tus.

Dua li ntawm kis cov kab mob sib kis, cov tiv thaiv kab mob tuaj yeem ua rau cov tshuaj tiv thaiv tom qab tau txais kev txhaj tshuaj (Kab mob vwm, Distemper, Panleukopenia, thiab lwm yam).

Cov tshuaj tua kab mob yog ib qho tseem ceeb rau kev tiv thaiv kab mob hauv lub cev, vim tias lawv pab txhawb kev paub txog cov kab mob yog li kev tiv thaiv lossis tsis tuaj yeem nqa mus nyob hauv lub cev.

Antibodies tsis yog ib txwm ua los ntawm peb lub cev; lawv tuaj yeem hloov mus nrog cov tswv cuab ntawm tib yam, lossis qee zaum txawv, hom. Piv txwv li, cov niam tsev hloov cov tshuaj tiv thaiv kab mob rau lawv cov menyuam ua ntej yug menyuam thaum tus menyuam tseem tab tom loj hlob, thiab tom qab ntawd lawv muab niam mis tso tawm thaum tseem noj niam mis.

Kev txhab ntshav nrog cov khoom lag luam zoo li ntshav kuj tseem tuaj yeem tso cov tshuaj tiv thaiv kab mob sib kis ntawm cov tswv cuab ntawm tib hom kom muab cov txiaj ntsig kev noj qab haus huv.

Lub MAb Cardiff yuav tau txais yog qhov txawv ntawm cov tshuaj tiv thaiv uas tuaj yeem sib koom tau hauv cov ntshav hloov ntshav lossis hla ntawm niam cov kua mis, lossis los ntawm cov tsim cov koob thib ob rau kev txhaj tshuaj tiv thaiv.

Dab tsi ua rau MAb Qhov Txiaj Ntsig uas yog Kev Kho Mob Rau Cardiff's Cancer?

MAb yog qhov tshwj xeeb yog qhov kev kho mob rau Cardiff's mob cancer vim tias nws muaj cov tshuab ntawm kev coj ua txawv dua li uas tsim los ntawm kev siv tshuaj kho mob. MAb tsis siv ncaj qha tua cov qog nqaij hlav cancer xws li kev siv tshuaj khomob. Hloov chaw, MAb “tsom lub cim tshwj xeeb nyob rau sab ntawm lub xov tooj. Thaum cov tshuaj tiv thaiv no khi nws, nws mam li ua rau lub cev tiv thaiv kab mob tua tus kabmob lossis qhia rau lub cell ua kev tua tus kheej, raws li Cardiff tus kws kho tsiaj txhu, Dr. Avenelle Turner ntawm Veterinary Cancer Group (Culver City, CA).

Dr. Turner tau koom nrog kev sim tshuaj sim ntawm MAb uantej nws yuav muaj kev tshaj tawm rau pej xeem, yog li kuv ntseeg txog nws qhov kev paub hauv lub neej tiag tiag los muab kev kho mob tshiab rau hauv nws txoj cai.

Vim Li Cas Kuv Thiaj Xav Tias MAb Ua Ib Feem Ntawm Cardiff Txoj Kev Kho Mob Mob?

Kev muab cov tshuaj kho mob Cardiff ib txwm cia yuav tiv thaiv cov qog ntshav tshiab los ntawm qhov tsis ua qog. Tseem muaj cov kev mob tshwm sim cuam tshuam nrog kev siv tshuaj kho mob.

Raws li Dr. Turner, "Piav qhia qhov tseeb ntawm kev kho hom phiaj yog kho tshwj xeeb kho qhov teeb meem / tus kab mob thaum kho cov nqaij mos thiab lub hlwb. MAb yuav tsum txhim kho cov txiaj ntsig thiab txo cov kev mob tshwm sim. Kev siv tshuaj ib txwm siv tua cov kab mob uas tau faib sai heev. Cov qog nqaij hlav cancer feem ntau yuav faib kom nrawm dua li cov qib hlwb, yog li qhov no yog vim li cas kev kho mob tua cov mob qog nqaij hlav tab sis kuj muaj cov kev mob tshwm sim thib ob vim tias lwm cov qog nyob hauv lub cev uas tau faib sai sai. Feem ntau, kev kho mob rau lub hom phiaj yog koom nrog kev siv tshuaj kho kom zoo tag nrho cov txiaj ntsig thiab nce lub sij hawm hloov kho tsis pub ntxiv thiab lub sijhawm muaj sia nyob."

Kuv cia siab tias Cardiff lub cev yuav ua siab ntev rau kev kho mob MAb, tshwj xeeb yog xav txog qhov muaj peev xwm ua rau muaj kev phiv loj heev ntawm qee cov tshuaj khomob xws li Hydroxydaunorubicin (cov tshuaj npe npe Doxorubicin lossis Adriamycin), uas paub txog nws cov kev puas tsuaj rau lub plawv.

Cov Teeb Meem Uas Yuav Muaj Feem Tau Dab Tsi Nrog Rau MAb?

Nrog rau ib qho kev kho mob twg, muaj peev xwm tshwm sim rau cov kev mob tshwm sim, txawm tias qhov yuav tshwm sim tsawg heev.

Kuv yog tag nrho rau kev siv cov khoom lag luam zoo li MAb ua tus txuas rau Cardiff cov tshuaj kho mob yog tias cov khoom lag luam pom tias muaj kev nyab xeeb txaus thiab yuav tsis muaj qee cov kev mob tshwm sim ib yam li nws tus CHOP raws tu qauv.

Vim nws yog qhov kev kho mob tshiab no, Kuv nrhiav Dr. Turner lub tswv yim. Nws hais tias “qee zaus koj tuaj yeem muaj hom-1 tshuaj tiv thaiv kev tiv thaiv tsis haum, uas yog tib cov tshuaj tiv thaiv uas tau sau tseg nrog peb kev tshawb fawb ob zaug. Nrog kev siv sijhawm ntev, koj tuaj yeem tsim kho kab mob auto-tiv thaiv kab mob (raws li pom nyob rau hauv tib neeg cov tshuaj), zoo li tshwm sim nrog R-CHOP (R sawv rau Rituxan) kev kho tshuaj rau B cell lymphoma hauv tib neeg. Peb tau txwv cov ntaub ntawv ntawm kev siv MAbs hauv kev kho tsiaj veterinary vim qhov no yog qhov kev kho tshiab."

Ib hom-1 cov tshuaj tiv thaiv kev tiv thaiv tsis haum yog suav tias yog kev tsis haum tshuaj sai uas ua rau muaj kev hloov pauv sai xws li urticaria (ua xua), angioedema (o), emesis (ntuav), raws plab, hypotension (ntshav siab), thiab lwm tus. Cov lus teb zoo li no tau hais txog qhov tshwm sim hauv qee cov dev vim kev plev los ntawm cov kab mob zoo li muv, hornets, thiab nkawj.

Kev muaj peev xwm rau hom-1 kev tiv thaiv tsis haum lub cev muaj feem nrog MAb tuaj yeem txo los ntawm kev tswj hwm kev noj tshuaj tiv thaiv kab mob antihistamine zoo li Diphenhydramine Hydrochloride (piv txwv li, Benadryl fab tshuaj).

Kev tswj hwm ntawm Diphenhydramine Hydrochloride raws li kev txhaj tshuaj yog qhov zoo tshaj li kev tswj hwm qhov ncauj vim qhov kev teb tau sai dua thiab muaj kev lees paub ntau ntxiv tias cov khoom yuav muaj cov txiaj ntsig xav tau. Tshuaj siv los tswj qhov ncauj yuav ntuav thiab tsis tas yuav muaj qhov siab tas li, yog li tso ib tus tsiaj rau muaj kev cuam tshuam tsis zoo.

Cardiff hais li cas rau T Cell Monoclonal Antibody Kev Kho Mob?

Raws li tam sim no qhov kev tshwm sim ntawm Cardiff tus kab mob yuav luag zoo ib yam li qhov uas nws muaj thaum Lub Kaum Ob Hlis 2013, nws cov lus teb rau kev phais mob thiab tshuaj lom neeg mob tau zoo heev. Nws maj mam kho ntawm kev phais mob thiab tiv taus nws cov tshuaj kho mob zoo heev.

Cardiff tau txais ib yam khoom hu ua Canine Lymphoma Monoclonal Antibody (T-cell), tsim los ntawm Aratana Kev Kho Mob, Inc. Thaum xub thawj, Cardiff tau txais MAb raws li kev tso ntshav ob zaug ib lim tiam rau plaub lub lis piam. Nws tau txais MAb txhua txhua lub lim tiam rau plaub qhov kev kho mob ntxiv.

Nws teb rau MAb tau zoo heev. Nws tsis pom kev ua rau lub ntsej muag tsis tshua zoo nkauj thiab feem ntau zoo li zoo tom qab nws txhaj tshuaj MAb. Feem ntau, nws tau pom tias nws qab los noj mov zoo dua nyob rau hnub, thiab feem ntau tau ob peb hnub, tom qab nws tau txais MAb ntxiv rau nws cov tshuaj kho mob.

Vam thiab cia siab, peb tabtom kawm Cardiff cov qe ntshav dawb kom paub txog thiab tshem tawm cov qog nqaij hlav cancer-lossis ua rau lawv "tua tus kheej" -tus siv MAb.

Yog tias koj xav paub txog kev siv MAb rau koj tus tsiaj, nco ntsoov sab laj nrog tus kws kho tsiaj oncologist ntawm nws cov muaj thiab sib raug.

Qhib lub sijhawm tom ntej rau kev rhuav tshem kuv kev siv nutraceuticals thiab tshuaj ntsuab los ua kev kho mob rau Cardiff txoj kev kho tshuaj thiab MAb. Nws yog lub ncauj lus hais txog qhov uas kuv tau mob siab rau thiab uas kuv siv rau txhua tus neeg mob qog nqaij hlav uas kuv muab saib xyuas.

Dr. Patrick Mahaney