Kab Mob Lub Hlwb Autoimmune Hauv Cov Dev

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Systemic Lupus Erythematosus (SLE) hauv dev

Systemic lupus erythematosus (SLE) yog ib hom kab mob multisystem autoimmune uas tau tsim los ntawm kev tsim cov tshuaj tiv thaiv tawm tsam ntau yam ntawm tus kheej-antigens (cov tshuaj tiv thaiv kab mob-tiv thaiv kab mob) thiab nthuav cov lub cev tiv thaiv kab mob. Hauv lwm lo lus, qhov no yog kab mob uas lub cev tiv thaiv kab mob hauv lub cev tau ua dhau los tiv thaiv kev kub ntxhov, tawm tsam cov hlwb, kabmob, thiab cov ntaub so ntswg ntawm nws tus kheej lub cev zoo li yog lawv muaj cov kab mob uas yuav tsum tau rhuav tshem.

Cov qib siab ntau ntawm cov ntshav ncig ua ntej-tiv thaiv kab mob (hom III lub cev tsis muaj zog) tau tsim thiab tso rau hauv qab glomerular hauv qab daim nyias nyias (ntu ntawm lub raum), cov leeg synovial (cov nqaij mos uas ua rau thaj chaw hauv cov pob qij txha xws li lub dab teg, lub hauv caug, thiab lwm yam), thiab hauv daim tawv nqaij, cov hlab ntsha, thiab lwm qhov chaw hauv lub cev. Cov tshuaj tua kab mob uas ua rau cov tshuaj tiv thaiv tus kheej uas nyob ntawm thiab sab hauv hlwb, xws li erythrocytes, leukocytes, thiab platelets (peb hom ntshav ntshav nrog hom II hypersensitivity), kuj tseem yuav tsim tau. Txog rau qib qis, hom IV kev tiv thaiv kab mob tsis txaus kuj tseem tuaj yeem koom nrog thaum cov cell-mediated tiv thaiv kev tiv thaiv tawm tsam tus kheej-antigen.

SLE yog qhov tsawg, tab sis ntseeg tau tias yog qhov ua qis dua. Qee yam ntawm cov tsiaj uas pom tias muaj tus thawj coj rau SLE suav nrog Shetland sheepdogs, tsoo pob, German tswv yug yaj, yaj cov laus lus Askiv, Afghan hound, beagles, Irish setters, thiab cov paws. SLE raug tshaj tawm tias muaj kev tsis sib haum xeeb hauv keeb kwm ntawm tus tswv yug yaj German. Lub hnub nyoog pes tsawg yog rau xyoo, tab sis nws tuaj yeem tshwm sim thaum muaj hnub nyoog. Tus tub los ntxhais tsis coj lub luag haujlwm.

Cov tsos mob thiab Hom

Cov tsos mob soj ntsuam nyob ntawm lub chaw ib ncig ntawm cov tshuaj tiv thaiv kab mob, nrog rau qhov tshwj xeeb ntawm cov mob autoantibodies. Txawm li cas los xij, caj ces, ib puag ncig, pharmacologic, thiab kab mob kis tau tuaj yeem ua lub luag haujlwm hauv qhov tsos ntawm kev kho mob xws li qhov ncauj, tsis qab los (tsis nco qab), thiab kub taub hau, uas yog pom tshwj xeeb tshaj yog nyob rau theem mob huam tuaj. Lwm yam paib muaj xws li:

Musculoskeletal

• Kev tso tawm ntawm lub cev tsis muaj zog hauv cov nqaij synovial (cov nqaij mos mos ua ob sab hauv qhov chaw hauv cov pob qij txha)
• O thiab / los yog mob tej pob qij txha - mob siab loj hauv cov neeg mob feem ntau
• Hloov txhais ceg lameness
• Kev mob los yog nkim nqaij

Daim tawv nqaij / exocrine

• Kev tso tawm ntawm cov tshuaj tiv thaiv kab mob hauv daim tawv nqaij
• Daim tawv nqaij mob
• Cov tawv nqaij ua sib xyaws los yog focal - ua pob liab, ntxaij, mob rau sab, qog, thiab / lossis plaub hau hle
• Ulceration ntawm mucocutaneous junctions thiab qhov ncauj mucosa tuaj yeem tsim - thaj av ntawm daim tawv nqaij suav nrog mucosa thiab tawv nqaij txiav; cov no feem ntau tshwm sim ze rau orifices ntawm lub cev uas cov tawv nqaij sab nraud nres thiab cov mucosa uas npog sab hauv ntawm lub cev pib (piv txwv li, qhov ncauj, qhov quav, qhov ntswg)

Hlaws pob / urologic

• Kev tso tawm ntawm kev tiv thaiv kab mob hauv lub raum
• Hepatosplenomegaly - kev loj hlob ntawm lub raum thiab mob siab

Ntshav / lymph / tiv thaiv kab mob

• Autoantibodies tiv thaiv erythrocytes, leukocytes, lossis platelets (cov ntshav liab thiab ntshav dawb)
• Lymphadenopathy - ua qog ntshav o
• Lwm yam khoom hauv nruab nrog cev tuaj yeem cuam tshuam yog tias muaj kev tso tawm ntawm cov txheej txheem tiv thaiv kab mob lossis tshuaj tiv thaiv, lossis thaum T cell-mediated hlwb (lymphocytes) tawm tsam.

Ua rau

Qhov tseeb ua rau SLE tsis muaj pov thawj, tab sis kev raug rau ultraviolet teeb ua rau hnyav dua tus kab mob.

Kev kuaj mob

Daim ntawv qhia txog cov ntshav yuav tsum tau ua, suav nrog daim ntawv qhia ntshav tshuaj, suav cov ntshav tiav, thiab zis cia. Koj yuav tsum tau muab cov keeb kwm kev nyab xeeb ntawm koj tus dev noj qab haus huv thiab pib cov tsos mob, thiab seb cov tsos mob tau tshwm sim hauv kev ua tiav, lossis tag nrho ib zaug. Kev mob ntawm pob qij txha, mob raum, mob tawv nqaij, qog cov ntshav liab, ntshav tsawg hauv lub cev, thiab lub cev tsis muaj zog yog tag nrho cov cim qhia uas yuav ceeb toom koj tus kws kho mob kom zoo li mob pob ntseg.

Kev Kho Mob

Kev mus pw hauv tsev kho mob tej zaum yuav tsim nyog rau kev tswj xyuas thawj zaug ntawm SLE, tshwj xeeb yog tias koj tus dev nyob hauv lub xeev ntawm kev mob hlwb (ntshav liab ntshav puas tsuaj) muaj teeb meem. Txawm li cas los xij, kev tswj hwm sab nrauv feem ntau tau yog tias tus mob tsis loj. Hom kev saib xyuas thiab qib kev saib xyuas yuav sib txawv los ntawm cov kev cuam tshuam los ntawm cov tshuab twg.

Txog kev kho mob hauv tsev, koj yuav tsum tswj txoj kev so, tshwj xeeb tshaj yog thaum lub sijhawm mob hnyav ntawm pob qij txha. Koj tuaj yeem xav txog lub vaj xov hlau so rau lub sijhawm luv luv, kom txog rau thaum koj tus dev tuaj yeem txav mus los tau zoo dua yam tsis muaj kev sab nraud. Koj tseem yuav tsum tau zam lub hnub ci ci, uas tej zaum yuav xav tau sijhawm teem sijhawm koj tus dev noj mov kom sijhawm mus ncig sab nraud tuaj yeem nqa thaum yav tav su / yav tsaus ntuj. Yog tias lub raum tab tom cuam tshuam, koj tus kws kho tsiaj yuav kom ib lub raum tso cov protein tsis zoo rau noj.

Muaj ntau cov tshuaj uas tuaj yeem siv los kho SLE, xws li cov tshuaj tiv thaiv kab mob rau txo qis hauv lub cev tiv thaiv kab mob, thiab corticosteroids rau kev txo qis mob hauv cov qog ntshav. Tus kws kho tsiaj yuav sau ntawv yuav tshuaj uas siv los kho ib hom mob uas muaj nyob hauv koj tus dev.

Kev Tiv Thaiv

Tsis txhob yug cov tsiaj cuam tshuam, vim tias SLE paub tias yuav muaj keeb kwm hauv qee hom tsiaj.

Nyob thiab Tswj

Nov yog kab mob huam vam thiab tsis muaj peev xwm piav tau. Lub sijhawm ntev, siv tshuaj tiv thaiv kom tsis txhob mob hnyav. Cov kev kho mob nquag muaj cov kev mob tshwm sim uas koj yuav xav tau nrog koj tus kws saib xyuas koj tus dev. Tsis tas li, koj tus kws kho tsiaj yuav xav pom koj tus dev txhua lub lim piam, tsawg kawg thaum pib, los saib xyuas qhov kev ua tau zoo ntawm kev kho thiab saib kom muaj kev phiv loj heev.