Txhawb Hormones Deev Hauv Dev

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Hyperandrogenism hauv dev

Hyperandrogenism hauv dev yog ib qho kev mob tsis tshua pom tshwm sim los ntawm kev sib deev ntawm cov txiv neej cov tshuaj hormones xws li testosterone thiab nws cov peev txheej hauv cov ntshav cov ntshav. Nws yog feem ntau teev qhia nyob hauv tus txiv neej cov dev.

Hauv cov txiv neej, androgens raug tsim los ntawm cov qe interstitial (cov hlwb hauv qhov chaw me me ntawm cov ntaub so ntswg) ntawm cov noob qes thiab ua lub luag haujlwm ntawm txiv neej kev sib deev. Androgens txhawb cov txiv neej zoo li tus cwj pwm thiab kev loj hlob ntawm lub cev, xws li spermatogenesis - kev tsim cov phev. Androgens suav nrog cov tshuaj steroid testosterone, androsterone, thiab dihydrotestosterone, uas yog ib qho kev sib txuas ntawm testosterone thiab kev siv tshuaj lom neeg (biologically-active metabolite) (cov tshuaj tseem ceeb rau cov txheej txheem hauv metabolic).

Dihydrotestosterone feem ntau yog tsim nyob hauv caj pas prostate caj pas, noob qes, cov hauv paus plaub hau, thiab qog adrenal. Androgens kuj tsim tawm los ntawm adrenal cortex (thaj chaw raws li puag ncig ntawm lub qog adrenal ze rau ob lub raum), thiab los ntawm cov zes qe menyuam hauv cov maum.

Hyperandrogenism yuav tshwm sim vim cov noob qes ntau dhau los ntawm cov noob qes, zes qe menyuam, lossis adrenal cortex. Lub tom kawg yuav tshwm sim theem nrab rau kev ua tsis tau zoo enzyme. Hyperandrogenism tseem yuav tshwm sim hauv kev koom tes nrog kev tswj hwm ntawm hluavtaws androgens.

Hyperandrogenism yuav tshwm sim los ntawm kev hloov pauv ntawm tus cwj pwm, kev txawv txav ntawm lub tsev me nyuam, thiab cov teeb meem ntawm daim tawv nqaij. Qhov kev cuam tshuam no zoo li tshwm sim hauv Pomeranians, Chow Chows, Poodles, Keeshond, thiab Samoyeds.

Cov tsos mob thiab Hom

• Kev Ua Paum
• Stunted kev loj hlob
• Cov plaub hau poob - ob tog sib tshooj, cuam tshuam rau caj dab, pob tw, caudal ncej puab, sab nraud ntawm pob ntseg, thiab Tail
• Qhuav, brittle plaub hau
• Hyperpigmentation ntawm daim tawv nqaij
• Cov plhaws

Poj niam

• Vaginitis (kis ntawm lub paum)
• Lub cev tsis xwm yeem (ib puag ncig ntawm "kub" hauv cov poj niam)
• Siv tshuaj loog ntev (lub caij nyoog nruab nrab ntawm estrus; uas ua rau tsis rov luam dua vim tias tsis muaj "kub")
• Virilization (kev txhim kho rau tus txiv neej cov yam ntxwv - qhov tseem ceeb hauv poj niam tus dev)
• Clitoral hypertrophy (ntev li ntawm clitoris)
• Kev txawv txav ntawm kev sib daj sib deev (nrog kev sib deev hauv utero)

Tus txiv neej

• Prostatomegaly (tshaj-ntawm prostate)
• Txawv txav ntawm cov phev morphology (qhov loj thiab cov qauv ntawm lub taub hau, nruab nrab thiab Tail)
• Circumanal gland hyperplasia - kev loj hlob ntawm cov hlwb hauv lub hws thiab cov qog sebaceous
• Prepubertal (tshwm sim ua ntej kev sib deev kom loj hlob)
• Kev loj hlob ntxov lub phaj kaw (lub cev tsis ua kom loj hlob ua ntej ua tiav puv loj)

Ua rau

• Kev tswj hwm sab nrauv ntawm androgens
• Ntxiv rau sab hauv androgen zais cia
• Rau poj niam, kis ntawm tus me nyuam hauv plab mus rau androgens
• Cov qog ua kom mob (feem ntau, theem nrab mus rau ib qho qe ntshav ntawm lub pob hauv qhov chaw hauv cov noob qes)

Kev kuaj mob

Koj tus kws kho tsiaj yuav ua tiav kev soj ntsuam lub cev rau koj tus dev, suav nrog cov ntshav tshuaj, ua kom tiav cov ntshav, lub rooj hluav taws xob, thiab tso zis, kom thiaj li txiav txim tau qee yam mob hauv lub cev, xws li hypothyroidism, hyperadrenocorticism, lossis hyperestrogenism. Ua tiav qhov kev ntsuam xyuas neurologic kuj yuav ua yog tias koj tus dev coj tsis zoo. Koj yuav tsum tau npaj kom muab koj tus kws kho tsiaj muaj keeb kwm zoo ntawm koj tus dev noj qab haus huv, qhov pib ntawm cov tsos mob, thiab keeb kwm caj ces uas koj paub zoo, yog tias muaj keeb caj ces. Nws tseem yuav pab tau yog tias koj paub txog kev noj qab haus huv ntawm koj tus dev cov niam tsev txiv tsev, thaum lub sijhawm thiab tom qab cev xeeb tub, nyob rau hauv cov ntaub ntawv muaj kev cuam tshuam tau kis ua ntej yug.

Cov duab hluav taws xob hauv lub cev lossis duab hluav taws xob kos duab tuaj yeem siv los ua kom pom qhov chaw sab hauv ntawm lub plab rau cov nqaij ntshiv lossis cov nqaij gonadal, uas ob qho no yuav yog qhov ua rau hyperandrogenism.

Ntxiv rau, muaj ntau qhov kev ntsuam xyuas uas yuav siv los ua kom muaj kev txheeb xyuas qhov tseeb: Karyotype, lossis kev tsom xam cov keebkwm, siv tau los tshawb qhov kev sib tshuam ntawm lub cev / gonadal kev sib deev tsis meej; cov ntshav dej piv txwv yuav raug ntsuas rau kev ntsuas cov tshuaj hormones poj niam txiv neej; kev loj hlob kev loj hlob hormone; ntsuas dej kuaj testosterone concentration; ib qho tshuaj adrenocorticotropic hormone (ACTH) kev sim tshuaj ntsuas txhawm rau ntsuas cov tshuaj adrenal teb rau ACTH (uas yog yam tshuaj tsim nyob rau hauv lub qog pituitary); thiab ib qho kev sim ntawm cortisol-creatinine piv rau hauv cov zis kom txiav tawm hyperadrenocorticism. Cov tshwm sim kuj yuav txawv.

Kev Kho Mob

Kev phais neutering ntawm cov tsiaj nyob ua si yog qhov kev pom zoo, thiab kev phais mob ntawm kev ntsuam xyuas seb muaj testosterone ntau npaum li cas lossis cov nqaij ua rau neoplastic (txawv txav) yuav tsum tau ua. Kev tswj kev rhuav tshem ntawm cov qog adrenal kuj tuaj yeem ua. Txoj kev loj hlob cov tshuaj hormones yuav raug tswj hwm, tab sis kev kho yuav nyob ntawm qee qhov ua rau koj tus dev hyperandrogenism.

Nyob thiab Tswj

Tom qab kev kho thawj zaug tau coj koj tus dev tus mob tuaj rau hauv kev tswjhwm, koj tus kws kho tsiaj yuav teem sijhawm mus ntsib kws kho mob txhawm rau ua raws li qhov ua tau zoo thiab kho lwm yam kev mob ntxiv lossis lwm yam kev mob. Koj tus kws kho tsiaj yuav rov ua dua ACTH cov kev sim tshuaj ntsuam ntshav thiab kuaj ntshav kom paub tseeb cov ntshav testosterone yog tias nws pib loj, nrog rau kev kuaj mob lub cev kom paub tseeb tias koj tus dev tau rov qab zoo los ntawm cov teebmeem ntawm hyperandrogenism.