Hemoglobin Thiab Myoglobin Hauv Cov Zis Hauv Cov Dev

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Hemoglobinuria thiab Myoglobinuria hauv dev

Hemoglobin yog cov pa oxygen nyob rau hauv cov ntshav liab, nws kuj pab xa oxygen mus rau cov ntaub so ntswg, nrog rau cov xim uas ua rau cov ntshav liab. Kev puas tsuaj ntawm cov qe ntshav nyob rau hauv cov hlab ntshav tso hemoglobin rau hauv cov ntshav plasma (cov kab mob khaub thuas colroed kua teeb meem ntawm cov ntshav), qhov twg nws khi nrog haptoglobin, ntshav plasma protein uas ua haujlwm rau lub hom phiaj nrog khi nrog hemoglobin dawb kom tiv thaiv qhov poob ntawm hlau los ntawm lub cev. Thaum tag nrho cov haptoglobin tau siv tas, hemoglobin nchuav dua rau hauv cov ntshav, khi rov qab rau cov ntshav protein thiab hloov cov xim ntawm lub plasma los ntawm tsaus muag daj mus rau liab dawb. Qhov uas tsis muaj kev hem ntshav yog tom qab los ntawm lub raum.

Myoglobin ua haujlwm tib lub hom phiaj li hemoglobin tab sis tshwj xeeb rau cov leeg nqaij, thiab sib txawv los ntawm cov pa oxygen thiab carbon monoxide nws xa mus rau cov ntaub so ntswg (ntau dua, thiab tsawg dua, feem). Kev puas tsuaj rau cov nqaij mus tso cov myoglobin rau hauv cov ntshav ntshav, tab sis nws tsis khi rau cov protein. Yog li, cov ntshav plasma tsis hloov, thiab myoglobin tshem tawm sai los ntawm cov ntshav los ntawm daim siab thiab lub raum. Yog tias muaj hemoglobin ntau heev thiab myoglobin nyob rau hauv cov ntshav ntshav, cov protein no yuav tsis rov ua haujlwm ntxiv nyob rau hauv ob lub raum, thiab yuav hloov mus rau hauv cov zis.

Tsis tsuas yog hemoglobin thiab myoglobin ua rau lub raum puas tsuaj, tab sis lawv muaj nyob rau hauv cov ntshav qhia tau hais tias muaj cov pa oxygen nqa khoom tsawg, uas tuaj yeem ua rau lub siab puas, mob hnyav, thiab poob siab, txhua tus ua haujlwm ntxiv kom txo qis ntawm cov pa mus rau lub cev los ntawm cov leeg thiab cov ntshav. Ntxiv rau, kev rhuav tshem cov qe ntshav liab hauv cov hlab ntshav, nrog rau cov leeg mob hnyav, tuaj yeem coj mus nthuav tawm txoj hlab ntshav sib luag (DIC), feem ntau ua rau tuag ntshav txhaws.

Cov tsos mob thiab Hom

• Txhawb lub plawv dhia
• Tsis muaj lub zog, lethargy
• Ua npaws
• Cov pos hniav daj dawb lossis paj yeeb tinged
• Daim tawv daj thiab / lossis daj ntsiab muag (daj)
• Kev khuv xim thiab doog ntshav
• Cov ntshav hauv cov zis (zis yog xim liab lossis xim liab)

Ua rau

Qee qhov ua kom muaj mob hemoglobinuria thiab myoglobinuria tau teev nyob ntawm no.

• Kev raug mob thiab kev raug mob (kub hnyiab, tawm dag zog dhau, siv hluav taws xob)
• Cov kab mob kis tau (cov cab ntawm cov ntshav)
• Cov ntshav phosphate tsawg

• Hemoglobinuria:

  • Kab mob caj
  • Kev tiv thaiv kab mob-mediated hemolytic anemia

• Myoglobinuria:

  • Mob leeg mob
  • Tsoo raug mob
  • Ce heev
  • Ntev hnoos qeev / chua leeg

• Toxins, tshuaj, thiab khoom noj fab:

  • Tooj liab
  • Menadione (siv los ua ntxiv vitamin K)
  • Mercury
  • Methylene xiav
  • Acetaminophen (tso tshuaj mob)
  • Zinc
  • Dos
  • Dag nab

Kev kuaj mob

Tus kws kho tsiaj yuav kuaj ib ce ntawm koj tus dev, suav txog keeb kwm yav dhau los ntawm cov tsos mob thiab qhov xwm txheej uas yuav ua rau muaj tus mob no. Koj yuav tsum tau muab keeb kwm keeb kwm ntawm koj tus dev noj qab haus huv thiab cov haujlwm tsis ntev los no. Daim ntawv qhia txog cov tshuaj ua ntshav tau tag, yuav suav nrog tag cov ntshav, thiab kuaj ntsuas seb puas muaj tshuaj lom tsawg ntawm tooj thiab zinc. Koj tus kws kho mob kuj tseem yuav tso ntshav pleev saib seb puas muaj cov ntshav liab liab txaus rau tsis txaus, thiab kuj tseem yuav siv cov tshuaj ammonium sulfate kuaj txhawm rau kuaj hemoglobin lossis myoglobin muaj nyob hauv cov ntshav.

Txoj hlab cia mus nrhiav bilirubin hauv cov zis yog lwm qhov kev sim uas yuav tsim nyog rau kev txheeb xyuas qhov tseeb tus mob tus mob. Bilirubin yog cov xim liab-daj bile xim uas los ntawm qhov ua paug ntawm cov xim liab (heme) hauv hemoglobin; ntau dhau bilirubin tsis tuaj yeem ua los ntawm daim siab thiab yuav txeej mus rau hauv cov zis. Kev siv bilirubin ntau dhau hauv cov ntshav kuj tseem ua rau lub cev tawv nqaij thiab tawv nqaij daj.

Cov ntawv xoo hluav taws xob thiab cov tshuab hluav taws xob yog cov khoom siv zoo rau pom tau lub siab ua haujlwm rau lub cev tiv thaiv kab mob tooj liab, lossis qhia tawm cov npib lossis cov xaum npaws / cov noob txiv ntoo - ob qho tib si no yog qhov sib txawv ntawm zinc lossis tooj liab lom.

Kev Kho Mob

Cov tshuaj uas tau sau tseg yuav yog nyob ntawm koj tus kws kho tsiaj yam mob kawg ntawm kev soj ntsuam tus mob. Yog tias qhov mob hnyav, koj tus dev yuav raug coj mus pw hauv tsev kho mob kom ruaj khov thiab tso dej tawm.

Nyob thiab Tswj

Tus kws kho tsiaj yuav qhia koj rau thaum twg koj yuav tsum tau rov qab los nrog koj tus dev mus ntsib sijhawm. Tej zaum yuav muaj kev xav tau txuas ntxiv rau cov ntshav chemistry profile, ua tiav cov ntshav suav, urinalysis, ntim cov ntim ntawm tes (PCV), thiab tshuaj xyuas ntshav ntawm lub plawv. Cov kab mob caj ces feem ntau tsis tuaj yeem kho, tab sis qee zaum tuaj yeem tswj hwm los ntawm kev noj qee qhov kev ceev faj nrog koj tus dev. Piv txwv, neonatal isoerythrolysis, mob ntshav qab zib uas ua rau muaj cov qe ntshav liab ua kom puas tsuaj, tuaj yeem tiv thaiv los ntawm kev tsis pub greyhounds nrog exertional myopathies (mob leeg) rau haiv neeg; txwv tsis pub muaj kev tawm dag zog ua Old English Sheepdogs nrog exertional lactic acidosis (ntshav tsis txaus ntawm cov acids nyob rau hauv cov ntshav); thiab txwv tsis pub Bedlington thiab West Highland Kev Nyab Xeeb Thaj Tsam nrog cov kab mob ntsig txog tooj liab tuaj mus rau hauv kev sib cuag nrog tooj liab.