Kuaj Tshuaj Tua Kab Mob Rau Tus Aub Uas Muaj Mob Khees Xob Rov Qab

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Tam sim no hais tias Cardiff tau zoo los ntawm kev phais mob kom tshem tawm nws txoj hnyuv me thiab cuaj ntawm daim tawv nqaij, nws yog lub sijhawm los nrhiav txoj kev npaj khomob rau tshuaj. Qhov no tsis yog thawj zaug Cardiff tau ua tus kws kho mob, raws li nws thawj chav kawm tau koom nrog xya lub hlis ntawm University of Witutionson-Madison Canine Lymphoma Protocol (aka CHOP), xaus rau lub Xya Hli 2014.

Ib feem ntawm kuv tau hais tsis sib haum txog qhov muab tshuaj rau nws dua, vim nws yog qhov tseem ceeb nyob rau hauv kev zam txim tam sim no tias nws mob cancer tau raug tshem tawm ntawm nws lub cev thiab tsis muaj lwm yam kab mob uas pom tau. Txawm li cas los xij, kuv xav muab nws txoj kev zoo tshaj plaws uas muaj lub neej zoo uas kav ntev dua ob peb lub hlis, thiab cov qog nqaij hlav cancer tseem tuaj yeem ua rau hauv nws lub cev uas yuav dhau los ua cov qog tshiab nyob rau ob peb lub hlis tom ntej mus rau lub hlis (saib Microscopic vs Cov Kab Mob Macroscopic - Qhov Sib Txawv Yog Dab Tsi?). Tsis tas li ntawd, Cardiff tau zam nws cov tshuaj kho mob kom zoo lub sijhawm dhau los uas kuv vam tias nws yuav ua li ntawd dua.

Kuv muaj hmoo tau txais lub tswv yim npaj tshuaj kho mob los ntawm Veterinary Cancer Group's Avenelle Turner DVM, Diplomate ACVIM (Oncology), vim tias kuv tsis tau paub txaus txog kev siv tshuaj kho mob los tswj hwm tus txheej txheem kuv tus kheej.

Cardiff cov txheej txheem yav dhau los yuav koom nrog plaub cov tshuaj muab nrog ua ke lossis ib tus zuj zus dhau li ntawm yim lub lim tiam rov ua haujlwm. Cov tshuaj no tau paub los ntawm acronym CHOP, uas sawv rau:

Cyclophosphamide (hom tshuaj npe Cytoxan)

Raws li tus neeg sawv cev alkylating, cov teebmeem ntawm Cyclophosphamide yog khi rau cov DNA ntawm tes kom tiv thaiv kev faib tawm ntawm tes thiab ua rau kev tuag ntawm tes. Hmoov tsis zoo, Cyclophosphamide tsis yog tshwj xeeb rau cov qog nqaij hlav cancer, yog li cov kab mob ib txwm tuaj yeem cuam tshuam thiab tua nyob rau hauv tus txheej txheem ntawm kev ua tiav cov nyhuv los tiv thaiv tus mob cancer. Kev faib cov hlwb sai sai yog cov uas muaj qhov txaus ntshai tshaj plaws, yog li ntawd cov kab mob ib txwm nyob hauv txoj hnyuv, suav nrog cov hlwb pob txha, thiab tso cai rau kev rov ua dua tshiab muaj feem cuam tshuam nrog rau cov qog nqaij hlav cancer.

Lub plab zom zaub mov (tsis qab los noj mov, ntuav, thiab raws plab) thiab hlwb pob txha tsaj yog cov kev phiv tshuaj Cyclophosphamide ntau. Raws li Cardiff tau neutered, tsis muaj kev ntshai ntawm txo qis nws cov phev suav los ntawm kev kho nws nrog Cyclophosphamide lossis lwm yam kev siv tshuaj kho mob.

Hydroxydaunorubicin (hom tshuaj npe Doxorubicin lossis Adriamycin)

Hydroxydaunorubicin ua tau yog ib qho tshuaj tua kab mob uas tsim los ntawm cov kab mob Streptomyces peucetius, uas muaj cov yam ntxwv tiv thaiv mob qog. Zoo li Cyclophosphamide, Hydroxydaunorubicin kuj tua cov qe sai thiab muaj cov kev mob tshwm sim zoo ib yam. Tsis tau, Hydroxydaunorubicin yog cardiotoxic, yog li nws ua rau lub plawv mob hlwb thiab tuaj yeem ua rau mob los yog ua rau cov kab mob plhaw. Txhua qhov kev sib txuas ntxiv ntawm Hydroxydaunorubicin tsub kom muaj kev cia siab rau cardiotoxicity, yog li cov sijhawm ntau dua Cardiff tau txais nws ntau dua nws lub siab ua haujlwm yuav xav tau kev ntsuas los ntawm ECG (electrocardiogram) thiab echocardiogram (mob plawv).

Hydroxydaunorubicin tau raug lub npe hu ua "dab ntxwg nyoog liab," vim tias nws yog ib qho ntawm cov tshuaj kho mob uas feem ntau yuav ua rau cov kev mob tshwm sim tsis zoo.

Oncovin (cov tshuaj npe Vincristine Sulfate)

Zoo li Cyclophosphamide, Oncovin yog alkylating tus neeg sawv cev uas ua kev puas tsuaj ntawm tes DNA thiab tseem cuam tshuam nrog kev tsim qee cov amino acids. Nws kuj tseem muaj cov kev phiv zoo ib yam li Cyclophosphamide.

Prednisone

Prednisone yog ib lub corticosteroid tshuaj rau ntau tus tsiaj rau ntau yam mob, nrog thawj qhov cuam tshuam yog anti-inflammatory kom pab nrog kev ua xua.

Ua raws li cov koob tshuaj uas tau qhia tseg, Prednisone tuaj yeem muaj ib qho tshuaj tiv thaiv neoplastic / cytotoxic (tiv thaiv mob qog nqaij hlav / mob cell-tua), tshuaj tiv thaiv kab mob, lossis tshuaj tiv thaiv. Cov koob txhaj tshuaj ntau dua yog tshuaj tiv thaiv neoplastic / cytotoxic, koob tshuaj nrab-nrab yog cov tshuaj tiv thaiv kab mob, thiab qhov qis tshaj plaws yog tshuaj tua. Cov kev mob tshwm sim rau Prednisone yuav ua rau muaj txiaj ntsig zoo rau Cardiff cov neeg, vim tias nws yuav mob siab rau noj thiab haus txawm tias nws lub siab ntxhov siab los ntawm nws cov tshuaj kho mob. Qhov ua kom tsawg-qhov xav kom tshwm sim suav nrog tso zis ntau ntxiv thiab ua pa nyuaj.

Txhua lub lim tiam thaum rov ua haujlwm, Cardiff yuav tau txais Cyclophosphamide, Hydroxydaunorubicin, lossis Oncovin, ib qho kev txhaj tshuaj lossis kev tswj hwm qhov ncauj.

Hydroxydaunorubicin thiab Oncovin raug muab raws li hauv cov leeg txhaj thiab Cyclophosphamide yog qhov ncauj tswj hwm. Kev noj tshuaj Prednisone yuav raug tso tawm tib zaug hauv thawj ob peb lub lis piam ntawm kev kho mob hauv rab koob tshuaj thiab ntau zaus.

Nrog cov tshuaj txhaj, muaj kev txhawj xeeb rau kev ua kom sab nrauv, uas yog qhov chaw tawm ntawm cov leeg ntshav thiab ua rau cov ntaub so ntswg uas nyob ib sab. Peb ntsib qhov teeb meem no nrog Oncovin thaum lub caij kawg Cardiff yog kev kho cov tshuaj kho mob, tab sis hmoov zoo nws yooj yim daws nrog kev saib xyuas mob siab (saib pom qhov tsis tau xav txog ntawm Kev Kho Mob Kws Kho Mob). Nrog rau cov tshuaj noj ntawm qhov ncauj, muaj ntau lub peev xwm rau lub plab lossis txoj hnyuv ua pa thiab lub plab zom mov tshwm sim.

Hmoov zoo, Cyclophosphamide thiab Oncovin tau paub tias muaj cov txiaj ntsig ntawm kev tiv thaiv kab mob rau cov kab mob xws li Immune Mediated Hemolytic Anemia (IMHA), uas Cardiff tau tiv dhau plaub zaug hauv nws kaum xyoo ntawm lub neej. Ntawm nws qhov kawg IMHA tshwm sim thaum Lub Kaum Hlis 2014, Cardiff ua tiav nws cov tshuaj kho mob peb lub hlis ua ntej tab sis tsis tau tso rov qab rau Azathioprine (Imuran) vim nws tsis meej rau kuv thiab Cardiff pab pawg kws kho tsiaj hauv tsev kho mob tshwj xeeb thiab oncologist seb puas ua li ntawd.

Azathioprine yog qhov tshuaj tiv thaiv tshuaj tiv thaiv uas tau ua tiav kom nws tsis txhob tsim lwm IMHA rov qab yam tsis ua rau pom kev mob tshwm sim. Nyob rau thawj chav kawm ntawm CHOP, Azathioprine tau txuas mus ntxiv vim tsis pom muaj txiaj ntsig ntxiv rau hauv kev txhaj tshuaj tiv thaiv nws ntxiv rau CHOP. Cardiff tsis muaj lwm qhov tshwm sim IMHA thaum lub sijhawm CHOP, tab sis ib zaug CHOP ua tiav nws lub cev tiv thaiv kab mob tsis muaj lwm txoj kev npaj thiab nws rov qab rhuav tshem nws cov ntshav liab (saib Tus Kws Kho Mob Ua Dab Tsi Thaum Tus Tsiaj Muaj Kev Nyuaj Siab Kev Kho Mob Yav Dhau Los Tau Txais Mob Dua?).

Yog tias Cardiff tseem nyob hauv kev zam txim tom qab yim lub limtiam rov ua kom tiav, tom qab ntawv kho nws yuav muab txhua 14 hnub rau rau lub hlis. Yog tias nws tseem nyob hauv kev zam txim tom qab rau lub hlis, tom qab ntawd cov kev kho mob yuav muab 30 hnub rau qhov tsis muaj hnub kawg.

Kev siv tshuaj kho mob yuav tseem koom nrog kev kho mob tshiab hu ua T-cell monoclonal antibody (MAb). Nws yog ib tus neeg sawv cev tiv thaiv kev kho mob muaj qhov sib txawv ntawm kev siv tshuaj los ntawm CHOP tshuaj thiab yuav yog lub ncauj lus ntawm kuv tus tom ntej.

Yog li, xav kom peb muaj hmoo hauv kev pib siv tshuaj kho dua thiab nyob zoo rau cov hloov tshiab kawg.

Koj tus tsiaj puas tau mus ntsib kws kho mob qog nqaij hlav cancer lossis lwm yam mob? Xav qhia dawb rau koj txoj kev paub, qhov zoo los sis qhov tsis zoo, hauv cov lus.

Cardiff tau txais Hydroxydaunorubicin (Adriamycin), tseem hu ua "liab dab ntxwg nyoog"

Cardiff tau txais kev soj ntsuam los ntawm kws kho tsiaj oncologist, Dr. Avenelle Turner ntawm Veterinary Cancer Group hauv Culver City, CA

Dr. Patrick Mahaney

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