Steroids Rau Cov Dev - Aub Dab Tsov

2024 Tus sau: Daisy Haig | [email protected]. Kawg hloov kho: 2023-12-17 03:09

Los ntawm Jennifer Coates, DVM

Cov tshuaj steroid-lawv yog ib hom tshuaj uas cov tshuaj feem ntau tau muab rau cov dev. Tab sis koj puas paub tias muaj xya chav kawm ntawm cov tshuaj steroid, txhua qhov ntawm cov hauj lwm sib txawv hauv lub cev thiab muaj nws cov teeb tsa cov kev mob tshwm sim? Nyeem rau kawm kom paub meej qhov koj muab koj tus dev thiab cov teeb meem dab tsi koj yuav tsum tau saib xyuas.

Glucocorticoids

Glucocorticoids yog nyob deb ntawm cov tshuaj feem ntau ntawm cov tshuaj steroid siv hauv cov tshuaj kho tsiaj. Cov npe ntawm cov tshuaj glucocorticoid ntev thiab suav nrog cov npe paub xws li prednisone, prednisolone, triamcinolone, betamethasone, dexamethasone, flumethasone, fludrocortisone, hydrocortisone, thiab methylprednisolone. Ntawm cov koob tshuaj qis dua, glucocorticoids txo qhov mob. Thaum muab tshuaj ntau dua, lawv tau tiv thaiv lub cev tsis muaj zog. Glucocorticoids feem ntau siv los kho kev ua xua thiab tiv thaiv kab mob tiv thaiv kab mob tab sis kuj tseem siv tau yog tias tus dev muaj tus kab mob Addison (saib tshooj lus tom ntej), los kho kev poob siab, lossis hauv kev kho rau qee yam mob qog nqaij hlav.

Glucocorticoids tuaj yeem muab los ntawm kev txhaj tshuaj, qhov ncauj, tshuaj pleev, lossis nqus tau. Kev siv luv luv ntawm glucocorticoids feem ntau muaj kev nyab xeeb heev, tab sis thaum lawv yuav tsum tau txhaj ntau dua tshwj xeeb tshaj yog siv sijhawm ntev, lossis tsis tuaj yeem tiv thaiv kab mob tsawg kawg rau txhua lwm hnub siv, kev phiv tshuaj xws li cov hauv qab no ua rau muaj ntau dua:

- Kev nqhis dej ntau dua, tso zis thiab tshaib plab

- qhov muaj feem nkag tau yooj yim

- lub plab zom mov

- cov leeg tsis muaj zog

- kev coj tus cwj pwm txawv

- kev tsim kho Cushing's disease

Cov kev mob tshwm sim hnyav tuaj yeem tshwm sim ntau dua yog tias cov tshuaj glucocorticoid yuav tsum tau muab cov kab ke hauv system (los ntawm qhov ncauj lossis txhaj tshuaj) ntau dua li qhov chaw nyob hauv zos (piv txwv li, nqus tau, thov rau daim tawv nqaij, lossis ua kua muag).

Mineralocorticoids

Thaum cov dev muaj Addison's disease, lawv cov qog ua qog ua tsis tau txaus ntawm ob hom tshuaj steroids-glucocorticoids (tau piav qhia saum toj) thiab mineralocorticoids. Mineralocorticoids yog lub luag haujlwm rau kev saib xyuas qhov sib npaug ntawm dej thiab electrolytes hauv lub cev thaum glucocorticoids ua lub luag haujlwm hauv qhov kev ntxhov siab teb. Hloov chaw kho mineralocorticoids thiab glucocorticoids yog qhov tseem ceeb rau kev kho cov dev nrog Addison tus kab mob.

Desoxycorticosterone yog qhov ua haujlwm ntev, hno mineralocorticoid thaum fludrocortisone tuaj yeem muab rau qhov ncauj thiab muaj ob qho kev ua mineralocorticoid thiab glucocorticoid. Ob qho tshuaj ntawm cov tshuaj no zoo heev tab sis tuaj yeem ua rau nqhis dej ntau dua thiab tso zis. Cov kev mob tshwm sim loj dua feem ntau pom tsuas yog thaum dev noj tshuaj los dhau lossis tseg kiag qhov uas tau txais lawv cov tshuaj.

Adrenal Cortical Cov Hluav Taws Xob

Adrenocorticotropic hormone (tseem hu ua ACTH lossis corticotropin) thiab cosyntropin yog siv los kuaj xyuas dev cov kab mob Cushing's thiab Addison's kab mob. Cov tshuaj no tau muab los ntawm kev txhaj tshuaj raws li ib feem ntawm kev kuaj ntshav ACTH, uas txiav txim xyuas seb puas muaj cov qog adrenal ua haujlwm ib txwm tsis ua haujlwm. ACTH cov kev sim ntsuas tseem tseem siv los saib xyuas dev nrog Cushing's tus kab mob uas tau raug kho nrog cov tshuaj mitotane. Cov kev mob tshwm sim tsis zoo li cov tshuaj adrenal cortical steroids vim tias lawv tsis muab rau ntev.

Anabolic Steroids

Cov tshuaj anabolic steroids zoo li stanozolol, boldenone, thiab nandrolone tsis yog ib txwm siv hauv cov tshuaj veterinary ntxiv lawm tab sis qee zaus kuj tau tawm los txhawb kev qab los noj mov, txhawb qhov hnyav, nce lub zog, thiab kho cov ntshav khov uas cuam tshuam nrog mob ntev. Cov tshuaj anabolic steroids yuav tsum tsis txhob muab rau cov tsiaj uas tuaj yeem cev xeeb tub vim lawv paub tias ua rau muaj qhov mob tsis zoo ntawm lub hnub yug. Lwm qhov kev mob tshwm sim suav nrog kev ua me nyuam rau cov txivneej thiab cov pojniam, cov ntsha hauv lub cev, lub siab puas, thiab kev hloov tus cwj pwm.

Estrogens

Estradiol yog tshuaj xeeb tshuaj lom neeg. Diethylstilbestrol (DES) yog cov tshuaj siv hluavtaws feem ntau ntawm estrogen. Ob qho tib si yog cov tshuaj steroid uas feem ntau siv los kho mob tso zis rau poj niam cov dev thaum cov tshuaj noj zoo dua phenylpropanolamine (PPA) tsis ua cov txiaj ntsig tau txaus siab. Estrogens kuj tseem yuav muab rau cov poj niam dev los txhawb lawv kom nkag mus rau hauv tshav kub lossis kom khov kho cov dev txiv neej los kho tus mob benign prostatic hypertrophy (BPH). Estrogens tuaj yeem muaj ntau qhov kev phom sij ntau nrog rau cov mob pob txha uas ua rau cov ntshav tsis txaus, ua rau muaj kev phom sij ntawm lub tsev menyuam (pyometra), pojniam muaj txiv neej, thiab muaj ntau ntxiv ntawm qee hom mob cancer.

Progestins

Progestins yog cov tshuaj hormones steroid uas feem ntau raug txwv tsis pub hloov mus rau lub sijhawm kub lossis txo cov kev xeeb menyuam cuav hauv cov poj niam dev thiab kho benign prostatic hypertrophy hauv txiv neej dev. Lawv kuj tseem siv tau rau qee yam teeb meem ntawm daim tawv nqaij lossis kho tus cwj pwm tsis zoo. Megestrol acetate thiab medroxyprogesterone yog qhov feem ntau siv txoj cai progestins hauv dev. Cov kev mob tshwm sim muaj xws li ua rau nqhis dej ntau dua thiab tsis qab los, hloov pauv tus cwj pwm, hloov lub plab ntawm lub plab, thiab qhov muaj peev xwm nce ntxiv ntawm kev mob ntshav qab zib mellitus, acromegaly (kab mob hormonal uas ua rau lub taub hau loj dua), Cushing's disease, uterine kis (pyometra), kev muaj me nyuam, thiab qee hom mob qog noj ntshav.

Androgens

Danazol, mibolerone, thiab testosterone yog txhua tus piv txwv ntawm androgens, chav kawm ntawm cov tshuaj hormones steroid. Androgens muaj ntau yam kev siv xws li kho cov tshuaj hormones-cuam tshuam tso zis tsis txaus nyob hauv cov txiv neej dev, kev tiv thaiv kev kub cev thiab kev txo qhov tsis muaj menyuam hauv poj niam cov dev, thiab ua ib feem ntawm txoj kev kho rau qee yam kev tiv thaiv kabmob ntshav uas muaj ntshav tsis txaus. Masculinization ntawm cov poj niam dev, daim siab mob toxicity, thiab nce qib ntawm qee hom mob cancer yog qhov muaj kev txhawj xeeb uas muaj kev phom sij tshaj plaws.

Tus Pros thiab Cons ntawm Steroids rau cov dev

Cov tshuaj steroid yog cov tshuaj zoo heev uas tau cawm ntau tus neeg lub neej. Txawm li cas los xij, hom tshuaj siv yeeb tshuaj no tseem cuam tshuam nrog kev sib txuam ntawm kev phiv. Feem ntau, teeb meem tuaj yeem tiv thaiv lossis tswj hwm los ntawm kev siv cov tshuaj kho qis kawg rau lub sijhawm luv thiab lub sijhawm saib xyuas cov dev thaum lawv tseem nyob nrog cov tshuaj steroid. Tham nrog tus kws kho tsiaj txog qhov zoo thiab tsis zoo ntawm kev kho steroid nws yuav tsum tau pom zoo rau koj tus dev.